Which of the following is a major transmission method for C. diff?

C. diff, or Clostridioides difficile, is primarily transmitted through the fecal-oral route. This means that the bacteria are shed in the feces of infected individuals and can contaminate surfaces, hands, or food. The ingestion of spores from contaminated surfaces or hands leads to infection, especially in environments such as hospitals or long-term care facilities where the bacteria are prevalent.

Understanding that C. diff spores can survive on surfaces for extended periods emphasizes the importance of thorough hand hygiene and environmental cleaning in preventing the transmission of the infection. The fecal-oral route highlights the need for careful attention to sanitation and hygiene practices, particularly in healthcare settings where vulnerable populations are at higher risk of infection.